Serum Adiponectin, Visfatin, and Omentin Compared between Non-pregnant and Pregnant Women in Overall, Non-obese, and Obese subjects

Chantacha Sitticharoon, Xaynaly Souvannavong Vilivong, Roongrit Klinjampa, Malika Churintaraphan, Nay Chi Nway, Issarawan Keadkraichaiwat, Tripop Lertbunnaphong


Objective: This study aimed to compare serum adiponectin, visfatin, and omentin between non-pregnant and pregnant women in overall, non-obese, and obese subjects.
Methods: There were 40 pregnant and 33 non-pregnant women classified by body mass index (BMI) into non-obese or obese subjects. Fasting blood samples were collected in the morning for the non-pregnant group and before delivery for the pregnant group.
Results: Plasma glucose levels were significantly lower, but plasma insulin levels were significantly higher in pregnant when compared to non-pregnant women in overall, non-obese, and obese women (p<0.05 all). The homeostasis model assessment of insulin resistance (HOMA-IR) was significantly higher, but the quantitative insulin sensitivity check index (QUICKI) was significantly lower only in obese pregnant when compared to obese non-pregnant women (p<0.01 all). However, in non-obese women, HOMA-IR and QUICKI were comparable between pregnant and non-pregnant women. Serum adiponectin, visfatin, and omentin were significantly lower in pregnant compared to non-pregnant women in overall, non-obese, and obese groups (p<0.05 all). In pregnant women, serum adiponectin
and omentin levels were significantly lower in obese compared to non-obese pregnant women while serum visfatin levels were comparable in both groups. Serum adiponectin levels were highest followed by omentin and visfatin, respectively in both non-obese and obese pregnant groups. These results indicated that lower serum adiponectin, visfatin, and omentin in pregnant women might contribute to higher insulin resistance in pregnancy. Furthermore, serum adiponectin and omentin were reduced in increasing adiposity similarly to non-pregnant women.
Conclusion: Lower serum adiponectin, visfatin, and omentin in pregnant women might lead to decreased insulin sensitivity in these women. 


Adiponectin; insulin resistance; omentin; pregnancy; visfatin

Full Text:


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.


  • There are currently no refbacks.

Contact address:
Amornrat Sangkaew
Editorial Office Secretary
SiMR Bldg., 2nd Fl., Room No.207, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Tel: +662 419 2884 | Fax: +662 411 0593 | Email: