Serum Neuropeptide Y and Leptin Levels compared between Non-pregnant and Pregnant Women in Overall, Non-obese, and Obese Subjects

Chantacha Sitticharoon, Roongrit Klinjampa, Xaynaly Souvannavong Vilivong, Saimai Chatree, Peerada Boonpuan, Chanakarn Sripong, Nay Chi Nway, Tripop Lertbunnaphong

Abstract


Objective: The primary objective of this study was to compare serum NPY and leptin levels between non-pregnant and pregnant women in overall, non-obese, and obese subjects. The secondary objective was to compare these peptides between non-obese and obese pregnant women.
Methods: Fasting venous blood was collected from non-pregnant women before open abdominal surgery and from pregnant women when admitted to the delivery room during the latent phase of labor.
Results: There were 12 non-obese and 14 obese subjects in the non-pregnant group and 9 non-obese and 30 obese subjects in the pregnant group. Systolic blood pressure (SBP) was comparable, but heart rate (HR) was higher in pregnant compared to non-pregnant women. Mean±S.E.M serum NPY levels were lower in the pregnant than in the non-pregnant group in overall (0.54±0.02 and 1.34±0.08, respectively), non-obese (0.53±0.05 and 1.23±0.14, respectively), and obese (0.54±0.03 and 1.43±0.09, respectively) subjects (p<0.01 for all), but these were comparable between obese and nonobese pregnant subjects. Serum NPY was positively correlated with SBP (R=0.281, p<0.05), but negatively correlated with HR (R=-0.324, p<0.01). Serum leptin levels were not different between pregnant and non-pregnant groups, but were significantly higher in obese than non-obese pregnant subjects (p<0.001). Serum leptin levels were positively correlated with body weight, BMI, waist and hip circumferences in overall and pregnant subjects (p<0.001 all). 
Conclusion: In pregnancy, decreased NPY levels might be associated with inhibition of SBP rising as well as increased HR. Leptin levels might not be associated with pregnancy, but associated mainly with obesity.


Keywords


Neuropeptide Y; Leptin; non-pregnant; pregnant women

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